×

BEFORE USING THIS SITE, PLEASE GO THROUGH THE USE OF CAREFULLY TERMS AND CONDITIONS.
Our visitors may use this site free. And, the users using this site agree to comply and bound by the below mentioned terms of use. If you do not agree to the given terms and conditions after reviewing it thoroughly, you are requested not to use the site:
Acceptance of Agreement: The terms and conditions featured in this Terms and Conditions of use Agreement (Agreement) related to our site (the site) are agreed by you. This Agreement represents the complete and only agreement between you and us, and supersedes all prior or contemporaneous agreements, representations, warranties and understandings related to the Site, free product samples, the content, or freebie offers or services provided by or listed on the Site, and the subject matter of this Agreement. We can amend the Agreement any time and at any frequency without informing or specific notice to you. The latest Agreement will be posted on the site that can be reviewed by you prior to using the site. This Agreement may be amended by us at any time and at any frequency without specific notice to you. The latest Agreement will be posted on the Site, and you should review this Agreement prior to using the Site.
Copyright. The organization, content, design, graphics, and other materials related to this Site are protected under applicable copyrights and other proprietary laws, including but not limited to intellectual property laws. Without our prior written permission, the copying, reproduction, use, modification or publication of full or part of any such matters or any part of the Site by you is strictly prohibited.
Deleting and Modification. We reserve the right in our sole discretion, to edit or delete any documents, information or other content appearing on the Site, including this Agreement without any notice requirement or obligation to you.
Indentification. You agree to indemnify, defend and hold us, our officers, our share holders, our partners, attorneys and employees harmless from any and all liability, loss, damages, claim and expense, including reasonable attorney's fees, related to your violation of this Agreement or use of the Site.
Disclaimer. THE CONTENT, SERVICES, FREE PRODUCT SAMPLES AND FREEBIE OFFERS FROM OR LISTED THROUGH THE SITE ARE PROVIDED "AS-IS," "AS AVAILABLE," AND ALL WARRANTIES, EXPRESS OR IMPLIED, ARE DISCLAIMED, INCLUDING BUT NOT LIMITED TO THE DISCLAIMER OF ANY IMPLIED WARRANTIES OF TITLE, NON-INFRINGEMENT, MERCHANTABILITY, QUALITY AND FITNESS FOR A PARTICULAR PURPOSE, WITH RESPECT TO THIS SITE AND ANY WEBSITE WITH WHICH IT IS LINKED. THE INFORMATION AND SERVICES MAY CONTAIN BUGS, ERRORS, PROBLEMS OR OTHER LIMITATIONS. WE HAVE NO LIABILITY WHATSOEVER FOR YOUR USE OF ANY INFORMATION OR SERVICE. IN PARTICULAR, BUT NOT AS A LIMITATION, WE ARE NOT LIABLE FOR ANY INDIRECT, INCIDENTAL OR CONSEQUENTIAL DAMAGES (INCLUDING DAMAGES FOR LOSS OF BUSINESS, LOSS OF PROFITS, LOSS OF MONEY, LITIGATION, OR THE LIKE), WHETHER BASED ON BREACH OF CONTRACT, BREACH OF WARRANTY, NEGLIGENCE, PRODUCT LIABILITY OR OTHERWISE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. THE NEGATION OF DAMAGES SET FORTH ABOVE ARE FUNDAMENTAL ELEMENTS OF THE BASIS OF THE BARGAIN BETWEEN US AND YOU THE USER. THIS SITE AND THE INFORMATION WOULD NOT BE PROVIDED WITHOUT SUCH LIMITATIONS. NO ADVICE OR INFORMATION, WHETHER ORAL OR WRITTEN, OBTAINED BY YOU FROM US THROUGH THE SITE SHALL CREATE ANY WARRANTY, REPRESENTATION OR GUARANTEE NOT EXPRESSLY STATED IN THIS AGREEMENT. THE INFORMATION AND ALL OTHER MATERIALS ON THE SITE ARE PROVIDED FOR GENERAL INFORMATION PURPOSES ONLY AND DO NOT CONSTITUTE PROFESSIONAL ADVICE. IT IS YOUR RESPONSIBILITY TO EVALUATE THE ACCURACY AND COMPLETENESS OF ALL INFORMATION AVAILABLE ON THIS SITE OR ANY WEBSITE WITH WHICH IT IS LINKED.
Limits. We disclaim all responsibility or liability for any damages caused by viruses contained within the electronic file containing the form or document.. We disclaim any form of the liability to you for any incidental, special or consequential damages of any kind that may result from use of or inability to use the site.
Third-Party Website. All rules, terms and conditions, other policies (including privacy policies) and operating procedures of third-party linked websites will apply to you while on such websites. For the content, accuracy or opinions expressed in such Websites, we are not responsible, and we have also not investigated, monitored or checked for accuracy or completeness of such websites. Any linked Website inclusion on our Site does not imply endorsement or approval of the linked Website by us. This Site and the third-party linked websites are independent entities and neither party has authority to make any representations or commitments on behalf of the other. You are acting at your own risk if you decide to leave our Site and access these third-party linked sites.
Third-Party Products and Services. Our site advertise third-party linked websites from which you may purchase or otherwise obtain certain freebie offerings, sample goods, or free trial services. It must be fully understood that we do not operate or control the free offerings, products, or services offered by third-party linked websites. The responsibility solely lies with the third-party linked websites for all aspects of order processing, billing fulfillment, and customer services. For any transactions entered into between you and third-party linked websites we are not a party to it. You agree that use of such third-party linked websites is at your sole risk and is without warranties of any kind by us, expressed, implied or otherwise. Under no circumstances are we liable for any damages arising from the transactions between you and third-party linked websites or for any information appearing on third-party linked websites or any other site linked to or from our site.
Submissions. All ideas, notes, suggestions, concepts and other information send by you to us (collectively, "Submissions") shall be deemed and shall remain our sole property and shall not be subject to any obligation of confidence on our part. Without limiting the foregoing, we shall be deemed to own all known and hereafter existing rights of every kind and nature regarding the Submissions and shall be entitled to unrestricted use of the Submissions for any purpose, without compensation to the provider of the Submissions.
General. You agree that all actions or proceedings arising directly or indirectly out of this agreement, or your use of the site or any sample products, freebie offers or services obtained by you through such use, shall be litigated in the circuit court of Los Angeles County, California or the United States District Court for the Central District of California. you are expressly submitting and consenting in advance to such jurisdiction in any action or proceeding in any of such courts, and are waiving any claim that Los Angeles, California or the central district of California is an inconvenient forum or an improper forum based on lack of venue. This site is controlled by Perfect Insight, Inc. in the State of California, USA. As such, the laws of California will govern the terms and conditions contained in this Agreement and elsewhere throughout the Site, without giving effect to any principles of conflicts of laws.

  • “I am here to apologize…"

    "...we have been terribly and systematically misled for nearly 70 years in the United States…the science is there...[cannabis] doesn’t have a high potential for abuse, and there are very legitimate medical applications…it could compete with A LOT of things…we are on the cusp of a marijuana revolution

     

    - Dr. Sanjay Gupta, M.D., Assistant Professor of Neurosurgery at Emory University, CNN Chief Medical Correspondent, nominated by President Obama for U.S. Surgeon General

    "...therapeutic potential in almost all diseases affecting humans"

    "modulating [endocannabinoid system] activity may have therapeutic potential in almost all diseases affecting humans, including obesity/metabolic syndrome, diabetes and diabetic complications, neurodegenerative, inflammatory, cardiovascular, liver, gastrointestinal, skin diseases, pain, psychiatric disorders, cachexia, cancer, chemotherapy-induced nausea and vomiting, among many others.”

     

    -Dr. Pal Pacher, MD/PhD & Dr. George Kunos, MD/PhD, Senior Investigators at the National Institutes of Health, an agency of the U.S. Department of Health and Human Services

    “Cannabinoids are a pharmacologic treasure trove!”

    – Dr. Raphael Mechoulam, PhD, Professor of Medicinal Chemistry, Hebrew University. Known as the “Father of cannabinoid science" for discoveries of THC, CBD, and the endocannabinoid system.

    "...[no] significant side effects across a wide range of dosages"

    "pre-clinical research...has shown CBD to have a range of effects that may be therapeutically useful, including anti-seizure, antioxidant, neuroprotective, anti-inflammatory, analgesic, anti-tumor, anti-psychotic, and anti-anxiety properties. A review of 25 studies on the safety and efficacy of CBD did not identify significant side effects across a wide range of dosages...there is extensive information available with regard to its metabolism, toxicology, and safety”

     

    -Dr. Nora Volkow, M.D., Director, U.S. National Institute on Drug Abuse, testifying in front of congress in 2015.

    "Cannabinoids are found to have particular application as neuroprotectants"

    "Cannabinoid's [anti-oxidant properties] are useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. Cannabinoids are found to have particular application as neuroprotectants...such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidiol, are particularly advantageous..."

     

    -Summary of the U.S. government-owned patent (#6,630,507): "Cannabinoids as anti-oxidants and neuroprotectants."

  • HISTORY OF MEDICAL CANNABIS

    From the Egyptians to the Americans

    Cannabis’ long and storied history begins in 2900 BCE, when the Chinese emperor Fu Hsi espoused its popularity as a medicine for a variety of ailments. Over the next 3000 years, cannabis appeared in an astonishing number of religious and medicinal texts from across the world: in 1500 BCE, it was lauded in the Chinese Rh-Ya pharmacopeia for treating dozens of ailments; cannabis residue was found on the body of King Ramses II of Ancient Egypt, where it was prescribed for pain and glaucoma; the plant and its extracts were extolled as the most important of 10,000 medicines in the Venidad and the Vedas, the two most important texts for Zoroastrianism and Hinduism; and Roman and Greek medical texts from circa 0 CE cite cannabis as treatment for various forms of inflammation like gout and joint pain.

    This knowledge of cannabis’ medicinal power did not disappear after antiquity. The Oxford scholar and clergyman Robert Burton suggested cannabis as a treatment for depression in The Anatomy of Melacholy in 1621 while Napoleonic France widely prescribed it as treatment for pain and insomnia. By the middle of the 19th century, most countries around the world had accepted the varied uses of cannabis.


    In 1850, cannabis was admitted into the United States Pharmacopeia, an official standards-setting authority for all prescription and over-the-counter medications. There, it listed cannabis as a treatment for pain, opiate and alcohol addiction, epilepsy, and a dozen other conditions. American pharmaceutical companies like Eli Lilly produced standardized cannabis extracts for patients across the nation.

    By 1936, every US state had outlawed or heavily regulated cannabis consumption. New, synthetic, patentable, drugs like morphine were developed, replacing cannabis as the West’s preferred pain medication. Hysteria and misinformation about cannabis was spread by its opponents, pushing cannabis further and further from the medical canon. By 1970, marijuana was classified by the Controlled Substances Act as a Schedule I drug—one so dangerous as to not have any conceivable medical merit, lumping it together with drugs like heroin and LSD. This designation continues to this day, wherein the U.S. federal government prevents the medical use of marijuana and blocks research into the medical potential. Without adequate research, how can we have reliable information on the harms and benefits of cannabis use in humans?

    Cannabinoids and the Endocannabinoid System

    Cannabinoids are a family of molecules that are produced by both the cannabis plant and the human body. Cannabinoids from the cannabis plant interact with the human Endocannabinoid System--a complex system that scientists only recently discovered in the 1990's. The Endocannabinoid System is present is nearly all vertebrates on Earth, ranging from birds and reptiles, to fish and sea squirts, and is believed to have evolved nearly 300 million years ago. We know it is involved in a wide range of functions, including mood, memory, sleep, appetite, pain, stress response, immune function, metabolism, and homeostasis.

    Over eighty-five unique cannabinoids have been identified in the cannabis plant, while only a handful have been pharmacologically studied. Most cannabinoids in cannabis are nonpsychoactive, with one notable exception. The chemical mainly responsible for cannabis’ psychoactivity—including the euphoric and analgesic effects that have caused its demonization for the last 70 years—is tetrahydrocannabinol or THC.

    Because of its outright and visible effects, THC has been the most studied and characterized cannabinoid by far. THC has been shown to have mild to moderate analgesic ability, proving successful in treatment of cancer pain, as well as reducing the amount of opiods needed in acute, escape medication treatments. In animal studies, THC displays neuroprotective and anti-oxidant properties (which have been documented in Patent #6,630,507, owned by the U.S. federal government), making it a candidate for treatment of Alzheimer’s and other neurodegenerative disorders. We also see significant anti-depressant like effects of THC in animal trials. THC also exhibits anti-nausea and appetite stimulating properties, making it useful for patients undergoing chemotherapy or suffering from HIV/AIDs associated cachexia. However, THC's psychoactive properties are controversial and may limit its widespread, regular use as a medication. It is THC's lesser-known sister cannabinoid cannabidiol (CBD), that appears to have significantly more medical promise.

    Cannabidiol, or CBD, is the other main active constituent in cannabis and is an isomer of THC. While this molecule is non-psychoactive, (producing none of the intoxication that is associated with THC), it is no less physiologically active. Cannabidiol’s therapeutic actions are incredibly wide: it has not only anti-anxiety and anti-psychotic properties, but also potent antioxidant action that is stronger than a- and b-tocopherol (vitamin E) and ascorbate (vitamin C). CBD has also been shown to exert neuroprotective effects--animal studies have demonstrated CBD benefitting degenerative neurological disorders like Alzheimer’s Disease. CBD also has anti-inflammatory effects, demonstrating benefit in animal models of inflammatory bowel disease and Type 1 Diabetes. CBD's analgesic effects have also been demonstrated and may eventually prove useful for the treatment of a wide variety of pain, from arthritis to nerve pain. Preliminary studies suggest that CBD has a very favorable safety and side effect profile, making it an attractive option from a patient compliance standpoint.

    Thus far, we have briefly described the effects of the two most well characterized cannabinoids found in cannabis. Scientists have identified more than 80 other cannabinoids in cannabis, and for a vast majority of these we know very little about their pharmacologic effects. What discoveries lay in these other cannabinoids? What additional pharmacologic effects (both positive and negative) will we discover about cannabinoids like THC or CBD? What will our studies of cannabinoids tell us about our own Endocannabinoid System? From the evidence shown so far, this future is a promising one; and as our knowledge of cannabis and its cannabinoids grows, our world will surely grow NICER.